Proteolysis Targeting Chimeras for BTK Efficiently Inhibit B-Cell Receptor Signaling and Can Overcome Ibrutinib Resistance in CLL Cells

Arbel, YS; Katz, B; Gabizon, R; Shraga, A; Bronstein, Y; Kamdjou, T; Levin, AG; Perry, C; Avivi, I; London, N; Herishanu, Y

Herishanu, Y (corresponding author), Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.; Herishanu, Y (corresponding author), Tel Aviv Sourasky Med Ctr, Dept Hematol, Tel Aviv, Israel.

FRONTIERS IN ONCOLOGY, 2021; 11 ():

Abstract

Proteolysis targeting chimeras (PROTACs) are small molecules that form ternary complexes between their target and E3 ligase, resulting in ubiquitinati......

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