Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain

Kumar, HS; Moore, J; Steiner, AC; Sotirakis, E; Schaerli, B; Isnard-Petit, P; Thiam, K; Wolfer, DP; Boettger, EC

Wolfer, DP (通讯作者),Swiss Fed Inst Technol, Inst Human Movement Sci & Sport, D HEST, Zurich, Switzerland.;Wolfer, DP (通讯作者),Univ Zurich, Inst Anat, Zurich, Switzerland.

CELLULAR AND MOLECULAR LIFE SCIENCES, 2023; 80 (12):

Abstract

A common perception in age-related neurodegenerative diseases posits that a decline in proteostasis is key to the accumulation of neuropathogenic prot......

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