RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells

Zhang, Y; Liao, XH; Xie, HY; Shao, ZM; Li, DQ

Shao, ZM; Li, DQ (reprint author), Fudan Univ, Shanghai Med Coll, Shanghai Canc Ctr, Shanghai 200032, Peoples R China.; Shao, ZM; Li, DQ (reprint author), Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, Shanghai 200032, Peoples R China.; Shao, ZM; Li, DQ

ONCOTARGET, 2017; 8 (55): 94505

Abstract

Poly(ADP-ribose) polymerase 1 (PARP1), a critical DNA repair protein, is frequently upregulated in breast tumors with a key role in breast cancer prog......

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