Autophagy inhibition impairs leukemia stem cell function in FLT3-ITD AML but has antagonistic interactions with tyrosine kinase inhibition

Qiu, SW; Kumar, H; Yan, CC; Li, H; Paterson, AJ; Anderson, NR; He, JB; Yang, J; Xie, M; Crossman, DK; Lu, R; Welner, RS; Bhatia, R

Bhatia, R (通讯作者)，Univ Alabama Birmingham, Div Hematol & Oncol, Birmingham, AL 35294 USA.

LEUKEMIA, 2022; 36 (11): 2621

Abstract

The FLT3-ITD mutation is associated with poor prognosis in acute myeloid leukemia (AML). FLT3 tyrosine kinase inhibitors (TKIs) demonstrate clinical e......

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