Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity

Wertz, MH; Mitchem, MR; Pineda, SS; Hachigian, LJ; Lee, H; Lau, V; Powers, A; Kulicke, R; Madan, GK; Colic, M; Therrien, M; Vernon, A; Beja-Glasser, VF; Hegde, M; Gao, F; Kellis, M; Hart, T; Doench, JG; Heiman, M

Heiman, M (corresponding author), MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA.; Heiman, M (corresponding author), Picower Inst Learning & Memory, Cambridge, MA 02139 USA.; Heiman, M (corresponding author), Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.

NEURON, 2020; 106 (1): 76

Abstract

Unbiased in vivo genome-wide genetic screening is a powerful approach to elucidate new molecular mechanisms, but such screening has not been possible ......

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