Design, synthesis and anti-tumor evaluation of plinabulin derivatives as potential agents targeting β-tubulin

Fang, SY; Bi, SJ; Li, YN; Tian, S; Xu, HX; Fu, L; Wang, SX; Tang, Y; Qiu, PJ

Wang, SX; Tang, Y; Qiu, PJ (通讯作者)，Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Chinese Minist Educ, Yushan Rd, Qingdao 266003, Peoples R China.;Tang, Y (通讯作者)，Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China.;Qiu, PJ (通讯作者)，Pilot Natl Lab Marine Sci & Technol Qingdao, Ctr Innovat Marine Drug Screening & Evaluat, Qingdao 266237, Peoples R China.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 91 ():

Abstract

Plinabulin is a promising microtubule destabilizing agent in phase 3 clinical stage for treating non-small cell lung cancer. However, the high toxicit......

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