A case of class 3 MEK1 mutated metastatic colorectal cancer with a non-durable tumor marker response to MEK and ERK inhibitors

Wang, CK; Sandhu, J; Fakih, M

Fakih, M (reprint author), City Hope Comprehens Canc Ctr, Med Oncol & Therapeut Res, Bldg 51,Room 112,1500 E Duarte St, Duarte, CA 91010 USA.; Fakih, M (reprint author), City Hope Comprehens Canc Ctr, Clin Res, Bldg 51,Room 112,1500 E Duarte St, Duarte, C

JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2019; 10 (6): 1140

Abstract

Class 3 MEK1 mutations disrupt the negative regulatory helix region of MEK1 and drive constitutive activation of both pMEK and pERK that is independen......

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