A synthetic lethal approach to drug targeting of G-quadruplexes based on CX-5461

Jin, MY; Hurley, LH; Xu, H

Hurley, LH; Xu, H (通讯作者),Univ Arizona, R Ken Coit Coll Pharm, 1703 E Mabel St, Tucson, AZ 85724 USA.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 91 ():

Abstract

DNA G-quadruplex (G4) structures are enriched at human genome loci critical for cancer development, such as in oncogene promoters, telomeres, and rDNA......

Full Text Link