The deletion of mutant SOD1 via CRISPR/Cas9/sgRNA prolongs survival in an amyotrophic lateral sclerosis mouse model

Duan, WS; Guo, MR; Yi, L; Liu, YK; Li, ZY; Ma, YQ; Zhang, GS; Liu, YL; Bu, H; Song, XQ; Li, CY

Song, XQ; Li, CY (corresponding author), Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang 050000, Hebei, Peoples R China.; Song, XQ; Li, CY (corresponding author), Neurol Lab Hebei Prov, Shijiazhuang 050000, Hebei, Peoples R China.; Song, XQ; Li, CY (corresponding author), Inst Cardiocerebrovasc Dis, Shijiazhuang 050000, Hebei, Peoples R China.

GENE THERAPY, 2020; 27 (3-4): 157

Abstract

The superoxide dismutase 1 (SOD1) mutation is one of the most notable causes of amyotrophic lateral sclerosis (ALS), and modifying the mutant SOD1 gen......

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