NUPR1 protects against hyperPARylation-dependent cell death

Santofimia-Castano, P; Huang, C; Liu, X; Xia, Y; Audebert, S; Camoin, L; Peng, L; Lomberk, G; Urrutia, R; Soubeyran, P; Neira, JL; Iovanna, J

Iovanna, J (通讯作者)，Aix Marseille Univ, Ctr Rech Cancerol Marseille CRCM, Inst Paoli Calmettes, CNRS,UMR 7258,INSERM,U1068,Parc Sci & Technol Lum, Marseille, France.

COMMUNICATIONS BIOLOGY, 2022; 5 (1):

Abstract

NUPR1 binds to PARP1 and inhibits PARP1 activity in pancreatic cancer cells, with the NUPR1 inhibitor ZZW-115 abolishing the protective effect of NUPR......

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