A Positively Selected fur-R88H Mutation Enhances Helicobacter pylori Fitness in a High-Salt Environment and Alters Fur-Dependent Regulation of Gene Expression

Loh, JT; Struttmann, EL; Favret, N; Harvey, ML; Pakala, SB; Chopra, A; McClain, MS; Cover, TL

Cover, TL (通讯作者)，Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37235 USA.;Cover, TL (通讯作者)，Vanderbilt Univ, Med Ctr, Dept Pathol Microbiol & Immunol, Nashville, TN 37235 USA.;Cover, TL (通讯作者)，Murdoch Univ, Inst Immunol & Infect Dis, Murdoch, Australia.;Cover, TL (通讯作者)，Vanderbilt Univ, Med Ctr, Vanderbilt Inst Infect Immunol Inflammat, Nashville, TN 37235 USA.;Cover, TL (通讯作者)，Vet Affairs Tennessee Valley Healthcare Syst, Nashville, TN 37212 USA.

INFECTION AND IMMUNITY, 2023; 91 (2):

Abstract

Both Helicobacter pylori infection and a high-salt diet are risk factors for gastric cancer. We previously showed that a mutation in fur (encoding the......

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