Studies on the intracellular accumulation process of methotrexate and its correlation with the key protein using an LC-MS/MS method: a novel way to realize prospective individualized medication

Ouyang, ZH; Huang, J; Ren, Y; Li, HH; Ding, Y; Zhang, K; Jiang, L; Yu, P

Yu, P (corresponding author), Cent South Univ, Xiangya Sch Pharmaceut Sci, 172 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2021; 413 (7): 1799

Abstract

High-dose methotrexate (HDMTX) combined with leucovorin (LV) is the first-line drug therapy for many kinds of malignant tumors. However, the specific ......

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