Medicinal chemistry, pharmacology, and therapeutic potential of alpha-conotoxins antagonizing the alpha 9 alpha 10 nicotinic acetylcholine receptor

Li, X; Tae, HS; Chu, YY; Jiang, T; Adams, DJ; Yu, RL

Yu, RL (corresponding author), Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Chinese Minist Educ, 5 Yushan Rd, Qingdao 266003, Peoples R China.; Yu, RL (corresponding author), Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Rioprod, Qingdao 266003, Peoples R China.; Adams, DJ (corresponding author), Univ Wollongong, Illawarra Hlth & Med Res Inst IHMRI, Wollongong, NSW 2522, Australia.; Yu, RL (corresponding author), Qingdao Natl Lab Marine Sci & Technol, Innovat Platform Mar

PHARMACOLOGY & THERAPEUTICS, 2021; 222 ():

Abstract

alpha-Conotoxins are disulfide-rich and well-structured peptides, most of which can block nicotinic acetylcholine receptors (nAChRs) with exquisite se......

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