A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traits

Cai, MX; Xiao, JS; Zhang, SK; Wan, X; Zhao, HY; Chen, G; Yang, C

Yang, C (corresponding author), Guangzhou HKUST Fok Ying Tung Res Inst, Guangzhou 511458, Peoples R China.; Yang, C (corresponding author), Hong Kong Univ Sci & Technol, Dept Math, Hong Kong, Peoples R China.; Chen, G (corresponding author), Cent South Univ, Sch Comp Sci & Engn, Hunan Prov Key Lab Bioinformat, Changsha 410083, Peoples R China.

AMERICAN JOURNAL OF HUMAN GENETICS, 2021; 108 (4): 632

Abstract

The development of polygenic risk scores (PRSs) has proved useful to stratify the general European population into different risk groups. However, PRS......

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