Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial

Wang, J; Zhao, J; Yan, C; Xi, C; Wu, C; Zhao, J; Li, F; Ding, Y; Zhang, R; Qi, S; Li, X; Liu, C; Hou, W; Chen, H; Wang, Y; Wu, D; Chen, K; Jiang, H; Huang, H; Liu, H

Huang, H; Liu, H (通讯作者)，Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Beijing 100049, Peoples R China.;Huang, H; Liu, H (通讯作者)，Univ Chinese Acad Sci, Beijing 100049, Peoples R China.;Liu, H (通讯作者)，Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China.

CELL METABOLISM, 2022; 34 (5): 667

Abstract

Developing non-statin-based small compounds to battle the global epidemic of hyperlipidemia remains challenging. Here, we report the discovery of DC37......

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