Pan-cancer population pharmacokinetics and exposure-safety and -efficacy analyses of atezolizumab in patients with high tumor mutational burden

Shemesh, CS; Chan, P; Legrand, FA; Shames, DS; Das Thakur, M; Shi, JE; Bailey, L; Vadhavkar, S; He, X; Zhang, W; Bruno, R

Shemesh, CS (corresponding author), Genentech Inc, Dept Clin Pharmacol Oncol, 1 DNA Way, San Francisco, CA 94080 USA.

PHARMACOLOGY RESEARCH & PERSPECTIVES, 2020; 8 (6):

Abstract

We retrospectively investigated the pharmacokinetics and exposure-efficacy/safety relationships of single-agent atezolizumab based on tissue tumor mut......

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