Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells

Agnihotri, S; Mansouri, S; Burrell, K; Li, M; Mamatjan, Y; Liu, J; Nejad, R; Kumar, S; Jalali, S; Singh, SK; Vartanian, A; Chen, EX; Karimi, S; Singh, O; Bunda, S; Mansouri, A; Aldape, KD; Zadeh, G

Zadeh, G (reprint author), Princess Margaret Canc Ctr, MacFeeters Hamilton Ctr Neurooncol Res, Toronto, ON M5G 1L7, Canada.; Agnihotri, S (reprint author), Univ Pittsburgh, Sch Med, Childrens Hosp Pittsburgh, Rangos Res Ctr, 7th Floor,Bay 15,530,45th St,

CLINICAL CANCER RESEARCH, 2019; 25 (2): 844

Abstract

Purpose: Hexokinase II (HK2) protein expression is elevated in glioblastoma (GBM), and we have shown that HK2 could serve as an effective therapeutic ......

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