1H-Pyrrolo[3,2-b]pyridine GluN2B-Selective Negative Allosteric Modulators

Chrovian, CC; Soyode-Johnson, A; Wall, JL; Rech, JC; Schoellerman, J; Lord, B; Coe, KJ; Carruthers, NI; Nguyen, L; Jiang, XH; Koudriakova, T; Balana, B; Letavic, MA

Chrovian, CC (reprint author), Janssen Res & Dev LLC, 3210 Merryfield Row, San Diego, CA 92121 USA.

ACS MEDICINAL CHEMISTRY LETTERS, 2019; 10 (3): 261

Abstract

Herein, we disclose a series of selective GluN2B negative allosteric modulators containing a H-1-pyrrolo[3,2-b]pyridine core. Lead optimization effort......

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