Dimethyl fumarate attenuates cholestatic liver injury by activating the NRF2 and FXR pathways and suppressing NLRP3/GSDMD signaling in mice

Xu, ZQ; Tang, W; Xie, QL; Cao, XY; Zhang, MN; Zhang, XX; Chai, J

Zhang, XX; Chai, J (通讯作者)，Army Med Univ, Third Mil Med Univ,Affiliated Hosp 1, Inst Digest Dis PLA,Southwest Hosp, Cholestat Liver Dis Ctr,Dept Gastroenterol, Chongqing 400038, Peoples R China.;Zhang, XX; Chai, J (通讯作者)，Army Med Univ, Affiliated Hosp 1, Southwest Hosp,Third Mil Med Univ, Ctr Metab Associated Fatty Liver Dis, Chongqing 400038, Peoples R China.

EXPERIMENTAL CELL RESEARCH, 2023; 432 (2):

Abstract

The progression of cholestasis is characterized by excessive accumulation of bile acids (BAs) in the liver, which leads to oxidative stress (OS), infl......

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