CLK1/SRSF5 pathway induces aberrant exon skipping of METTL14 and Cyclin L2 and promotes growth and metastasis of pancreatic cancer

Chen, S; Yang, C; Wang, ZW; Hu, JF; Pan, JJ; Liao, CY; Zhang, JQ; Chen, JZ; Huang, Y; Huang, L; Zhan, Q; Tian, YF; Shen, BY; Wang, YD

Chen, S; Wang, YD (corresponding author), Fujian Med Univ, Shengli Clin Med Coll, 134 East St, Fuzhou 350001, Fujian, Peoples R China.; Shen, BY (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Res Inst Pancreat Dis, Dept Gen Surg,Pancreat Dis Ctr,Ruijin Hosp, 197 Ruijin Second Rd, Shanghai 200025, Peoples R China.

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021; 14 (1):

Abstract

Background Both aberrant alternative splicing and m6A methylation play complicated roles in the development of pancreatic cancer (PC), while the relat......

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