Mechanistic Pharmacokinetic/Pharmacodynamic Model of Sunitinib and Dopamine in MCF-7/Adr Xenografts: Linking Cellular Heterogeneity to Tumour Burden

Wang, SY; Zhu, X; Han, MY; Hao, FR; Lu, W; Zhou, TY

Zhu, X (corresponding author), Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.; Zhu, X (corresponding author), Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China.

AAPS JOURNAL, 2020; 22 (2):

Abstract

The self-renewal and differentiation of cancer stem-like cells (CSCs) leads to cellular heterogeneity, causing one of the greatest challenges in cance......

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