p19-targeted ABD-derived protein variants inhibit IL-23 binding and exert suppressive control over IL-23-stimulated expansion of primary human IL-17+T-cells

Krizova, L; Kuchar, M; Petrokova, H; Osicka, R; Hlavnickova, M; Pelak, O; Cerny, J; Kalina, T; Maly, P

Maly, P (reprint author), CAS, Inst Biotechnol, BIOCEV Res Ctr, Vvi, Prumyslova 595, Vestec 25250, Czech Republic.

AUTOIMMUNITY, 2017; 50 (2): 102

Abstract

Interleukin-23 (IL-23), a heterodimeric cytokine of covalently bound p19 and p40 proteins, has recently been closely associated with development of se......

Full Text Link