Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor

Zhang, XY; Choi, PS; Francis, JM; Gao, GF; Campbell, JD; Ramachandran, A; Mitsuishi, Y; Ha, G; Shih, J; Vazquez, F; Tsherniak, A; Taylor, AM; Zhou, J; Wu, Z; Berger, AC; Giannakis, M; Hahn, WC; Cherniack, AD; Meyerson, M

Meyerson, M (reprint author), Dana Farber Canc Inst, Boston, MA 02215 USA.

CANCER DISCOVERY, 2018; 8 (1): 108

Abstract

The Kruppel-like family of transcription factors plays critical roles in human development and is associated with cancer pathogenesis. Kruppel-like fa......

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