Inhibition of catechol-O-methyltransferase by natural pentacyclic triterpenes: structure-activity relationships and kinetic mechanism

Wang, FY; Wei, GL; Fan, YF; Zhao, DF; Wang, P; Zou, LW; Yang, L

Wang, P; Yang, L (corresponding author), Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai 201203, Peoples R China.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021; 36 (1): 1079

Abstract

Inhibitors of COMT are clinically used for the treatment of Parkinson's disease. Here, we report the first natural pentacyclic triterpenoid-type COMT ......

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