Amphiphilic Guanidinocalixarenes Inhibit Lipopolysaccharide (LPS)- and Lectin-Stimulated Toll-like Receptor 4 (TLR4) Signaling

Sestito, SE; Facchini, FA; Morbioli, I; Billod, JM; Martin-Santamaria, S; Casnati, A; Sansone, F; Peri, F

Peri, F (reprint author), Univ Milano Bicocca, Dept Biotechnol & Biosci, Piazza Sci 2, I-20126 Milan, Italy.; Sansone, F (reprint author), Univ Parma, Dipartimento Sci Chim Vita & Sostenibilita Ambien, Parco Area Sci 17-A, I-43124 Parma, Italy.

JOURNAL OF MEDICINAL CHEMISTRY, 2017; 60 (12): 4882

Abstract

We recently reported on the activity of cationic amphiphiles in inhibiting TLR4 activation and subsequent production of inflammatory cytokines in cell......

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