Impact of capacity-limited binding on recombinant factor VIII and von Willebrand factor pharmacokinetics in hemophilia A rats

Christensen, IV; Loftager, M; Rode, F; Nielsen, HM; Kreilgaard, M; Larsen, MS

Larsen, MS (reprint author), Novo Nordisk AS, Global Drug Discovery, Haemophilia Res, Malov, Denmark.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2019; 17 (6): 964

Abstract

Essentials Knowledge of the interplay between FVIII and VWF pharmacokinetics (PK) is lacking. We characterized the capacity-limited PK of FVIII and VW......

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