Concise syntheses and HCV NS5B polymerase inhibition of (2 ' R)-3 and (2 ' S)-2 '-ethynyluridine-10 and related nucleosides

Bennett, F; Buevich, AV; Huang, HC; Girijavallabhan, V; Kerekes, AD; Huang, YH; Malikzay, A; Smith, E; Ferrari, E; Senior, M; Osterman, R; Wang, LY; Wang, J; Pu, HY; Truong, QT; Tawa, P; Bogen, SL; Davies, IW; Weber, AE

Bennett, F (reprint author), Merck & Co Inc, MRL, Dept Med Chem, 2015 Galloping Hill Rd, Kenilworth, NJ 07033 USA.; Buevich, AV (reprint author), Merck & Co Inc, MRL, Dept Struct Elucidat, 2015 Galloping Hill Rd, Kenilworth, NJ 07033 USA.; Huang, HC (repr

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017; 27 (23): 5349

Abstract

(2'R)-Ethynyl uridine 3, and its (2'S)-diastereomer 10, are synthesised in a divergent fashion from the inexpensive parent nucleoside. Both nucleoside......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索