Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo

Uehara, S; Shimizu, M; Ple, K; Routier, S; Yoneda, N; Higuchi, Y; Suemizu, H; Yamazaki, H

Yamazaki, H (通讯作者)，Showa Pharmaceut Univ, Lab Drug Metab & Pharmacokinet, 3-3165 Higashi Tamagawa Gakuen, Machida, Tokyo 1948543, Japan.

DRUG METABOLISM AND PHARMACOKINETICS, 2022; 44 ():

Abstract

Polymorphic cytochrome P450 3A5 (CYP3A5) expression contributes to individual differences in the pharmacokinetics of probe drugs. The identification o......

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