Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

Runtsch, MC; Angiari, S; Hooftman, A; Wadhwa, R; Zhang, YL; Zheng, YA; Spina, JS; Ruzek, MC; Argiriadi, MA; McGettrick, AF; Mendez, RS; Zotta, A; Peace, CG; Walsh, A; Chirillo, R; Hams, E; Fallon, PG; Jayamaran, R; Dua, K; Brown, AC; Kim, RY; Horvat, JC; Hansbro, PM; Wang, C; O'Neill, LAJ

Runtsch, MC; O'Neill, LAJ (通讯作者)，Trinity Coll Dublin, Sch Biochem & Immunol, Trinity Biomed Sci Inst, 152-160 Pearse St, Dublin D02 R590, Ireland.

CELL METABOLISM, 2022; 34 (3): 487

Abstract

The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory response in pro-inflammatory M1 macrophages. However, alter......

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