A microfluidic oxygen gradient demonstrates differential activation of the hypoxia-regulated transcription factors HIF-1 alpha and HIF-2 alpha

Rexius-Hall, ML; Rehman, J; Eddington, DT

Eddington, DT (reprint author), Univ Illinois, Coll Engn, Dept Bioengn, Chicago, IL 60612 USA.; Eddington, DT (reprint author), Coll Med, Chicago, IL 60612 USA.; Rehman, J (reprint author), Univ Illinois, Coll Med, Dept Pharmacol, Chicago, IL 60612 USA.;

INTEGRATIVE BIOLOGY, 2017; 9 (9): 742

Abstract

Gas-perfused microchannels generated a linear oxygen gradient via diffusion across a 100 mm polydimethylsiloxane (PDMS) membrane. The device enabled e......

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