Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors

Wang, YY; Ma, H; Huang, JX; Yao, ZG; Yu, JQ; Zhang, WN; Zhang, LC; Wang, ZB; Zhuang, CL

Wang, ZB; Zhuang, CL (corresponding author), Second Mil Med Univ, Sch Pharm, 325 Guohe Rd, Shanghai 200433, Peoples R China.; Zhang, LC (corresponding author), Shanghai Municipal Hosp Tradit Chinese Med, Dept Pharm, 274 Middle Zhijiang Rd, Shanghai 200071, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 212 ():

Abstract

Necroptosis is a form of programmed cell death that contributes to the pathophysiology of cerebral ischemia/reperfusion (I/R) injury. In this study, b......

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