Inhibition of USP10 induces degradation of oncogenic FLT3

Weisberg, EL; Schauer, NJ; Yang, J; Lamberto, I; Doherty, L; Bhatt, S; Nonami, A; Meng, CC; Letai, A; Wright, R; Tiv, H; Gokhale, PC; Ritorto, MS; De Cesare, V; Trost, M; Christodoulou, A; Christie, A; Weinstock, DM; Adamia, S; Stone, R; Chauhan, D;

Weisberg, EL (reprint author), Harvard Med Sch, Dept Med Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA.; Buhrlage, SJ (reprint author), Harvard Med Sch, Dept Canc Biol, Dana Farber Canc Inst, Boston, MA 02115 USA.; Buhrlage, SJ (reprint author), Harv

NATURE CHEMICAL BIOLOGY, 2017; 13 (12): 1207

Abstract

Oncogenic forms of the kinase FLT3 are important therapeutic targets in acute myeloid leukemia (AML); however, clinical responses to small-molecule ki......

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