Rigidity of the extracellular part of HER2: Evidence from engineering subdomain interfaces and shared-helix DARPin-DARPin fusions

Jost, C; Stuber, JC; Honegger, A; Wu, YF; Batyuk, A; Pluckthun, A

Pluckthun, A (reprint author), Univ Zurich, Dept Biochem, Winterthurerstr 190, CH-8057 Zurich, Switzerland.; Pluckthun, A (reprint author), Mol Partners AG, DARPin Technol, Zurich, Switzerland.

PROTEIN SCIENCE, 2017; 26 (9): 1796

Abstract

The second member of the human ErbB family of receptor tyrosine kinases, HER2/hErbB2, is regarded as an exceptional case: The four extracellular subdo......

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