Single-cell multiomics analyses of spindle-transferred human embryos suggest a mostly normal embryonic development

Qi, SY; Wang, W; Xue, XH; Lu, Z; Yan, J; Li, YF; Zhang, Y; Shu, MM; Song, CL; Wang, QH; Chuai, YH; Zhai, XY; Han, SJ; Tang, FC; Shang, W

Tang, FC; Shang, W (通讯作者)，Peking Univ, Sch Life Sci, Biomed Pioneering Innovat Ctr, Beijing, Peoples R China.;Shang, W (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Med Ctr 7, Dept Obstet & Gynecol, Beijing, Peoples R China.;Shang, W (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China.;Tang, FC (通讯作者)，Peking Univ, Peking Univ Tsinghua Univ Natl Inst Biol Sci Join, Acad Adv Interdisciplinary Studies, Beijing, Peoples R China.;Tang, FC (通讯作者)，Minist Educ,

PLOS BIOLOGY, 2022; 20 (8):

Abstract

Mitochondrial DNA (mtDNA) mutations are often associated with incurable diseases and lead to detectable pathogenic variants in 1 out of 200 babies. Un......

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