Pentosan polysulfate inhibits IL-1 beta-induced iNOS, c-Jun and HIF-1 alpha upregulation in canine articular chondrocytes

Bwalya, EC; Kim, S; Fang, J; Wijekoon, HMS; Hosoya, K; Okumura, M

Bwalya, EC (reprint author), Hokkaido Univ, Grad Sch Vet Med, Dept Vet Clin Sci, Lab Vet Surg, Sapporo, Hokkaido, Japan.

PLOS ONE, 2017; 12 (5):

Abstract

Osteoarthritic (OA) chondrocytes are shown to express inducible nitric oxide synthase (iNOS) which produces high concentrations of nitric oxide (NO), ......

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