Preclinical investigation of a potent geranylgeranyl diphosphate synthase inhibitor

Haney, SL; Chhonker, YS; Varney, ML; Talmon, G; Murry, DJ; Holstein, SA

Holstein, SA (reprint author), Univ Nebraska Med Ctr, Dept Internal Med, 986840 Nebraska Med Ctr, Omaha, NE 68198 USA.; Holstein, SA (reprint author), Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE 68198 USA.

INVESTIGATIONAL NEW DRUGS, 2018; 36 (5): 810

Abstract

Geranylgeranyl diphosphate synthase (GGDPS) is the enzyme in the isoprenoid biosynthesis pathway that catalyzes the synthesis of the 20-carbon isopren......

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