Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1

Mabbitt, J; Holyer, ID; Roper, JA; Nilsson, UJ; Zetterberg, FR; Vuong, L; Mackinnon, AC; Pedersen, A; Slack, RJ

Slack, RJ (通讯作者)，Galecto Biotech AB, Stevenage Biosci Catalyst, Stevenage, England.

FRONTIERS IN IMMUNOLOGY, 2023; 14 ():

Abstract

BackgroundGalectin-3 (Gal-3) is a & beta;-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive canc......

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