Acidic Microenvironment Regulates the Severity of Hepatic Ischemia/Reperfusion Injury by Modulating the Generation and Function of Tregs via the PI3K-mTOR Pathway

Gan, XJ; Zhang, RS; Gu, J; Ju, Z; Wu, X; Wang, Q; Peng, H; Qiu, JN; Zhou, JR; Cheng, F; Lu, L

Cheng, F; Lu, L (corresponding author), Nanjing Med Univ, Affiliated Hosp 1, Hepatobiliary Ctr, Nanjing, Peoples R China.; Cheng, F; Lu, L (corresponding author), Chinese Acad Med Sci, Res Unit Liver Transplantat & Transplant Immunol, Nanjing, Peoples R China.; Cheng, F; Lu, L (corresponding author), Chinese Acad Med Sci, Key Lab Liver Transplantat, Nanjing, Peoples R China.; Cheng, F; Lu, L (corresponding author), Natl Hlth Commiss, Key Lab Living Donor Liver Transplantat, Nanjing, Peoples R China.

FRONTIERS IN IMMUNOLOGY, 2020; 10 ():

Abstract

Hepatic ischemia/reperfusion injury (HIRI) is a major cause of liver dysfunction and even liver failure after liver transplantation and hepatectomy. O......

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