Low-dose Btk inhibitors selectively block platelet activation by CLEC-2

Nicolson, PLR; Nock, SH; Hinds, J; Garcia-Quintanilla, L; Smith, CW; Campos, J; Brill, A; Pike, JA; Khan, AO; Poulter, NS; Kavanagh, DM; Watson, S; Watson, CN; Clifford, H; Huissoon, AP; Pollitt, AY; Eble, JA; Pratt, G; Watson, SP; Hughes, CE

Nicolson, PLR; Watson, SP (corresponding author), Univ Birmingham, Coll Med & Dent Sci, Inst Cardiovasc Sci, Birmingham, W Midlands, England.; Nicolson, PLR (corresponding author), Queen Elizabeth Hosp, Dept Haematol, Birmingham, W Midlands, England.; Hughes, CE (corresponding author), Univ Reading, Inst Cardiovasc & Metab Res, Harborne Bldg, Reading, Berks, England.; Watson, SP (corresponding author), Univ Birmingham, Ctr Membrane Prot & Receptors COMPARE, Midlands, England.; Watson, SP (corres

HAEMATOLOGICA, 2021; 106 (1): 208

Abstract

Inhibitors of Bruton tyrosine kinase (Btk) have been proposed as novel antiplatelet agents. In this study we show that low concentrations of the Btk i......

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