The Safety, Pharmacokinetics, and Pharmacodynamics of SHR2285, an Oral Small Molecule Factor XIa Inhibitor, in Healthy Chinese Volunteers

Xu, JY; Zhao, N; Huang, J; Li, JL; Zhao, X; Xiang, Q; Yang, SB; Dong, YL; Wang, HH; Li, YJ; Yang, GP; Cui, YM

Cui, YM (通讯作者)，Peking Univ First Hosp, Dept Pharm, Beijing, Peoples R China.;Yang, GP (通讯作者)，Cent South Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, Changsha 410013, Hunan, Peoples R China.;Cui, YM (通讯作者)，Peking Univ, Sch Pharmaceut Sci, Dept Pharm Adm & Clin Pharm, Beijing, Peoples R China.;Cui, YM (通讯作者)，Peking Univ, Inst Clin Pharmacol, Beijing, Peoples R China.

CLINICAL DRUG INVESTIGATION, 2023; 43 (6): 435

Abstract

Background and ObjectiveThere is an unmet need for a safer anticoagulant since bleeding remains a concern with currently approved anticoagulants. Coag......

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