mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease

Ast, A; Buntru, A; Schindler, F; Hasenkopf, R; Schulz, A; Brusendorf, L; Klockmeier, K; Grelle, G; McMahon, B; Niederlechner, H; Jansen, I; Diez, L; Edel, J; Boeddrich, A; Franklin, SA; Baldo, B; Schnoegl, S; Kunz, S; Purfurst, B; Gaertner, A; Kampin

Wanker, EE (reprint author), Max Delbrueck Ctr Mol Med, Neuroprote, D-13125 Berlin, Germany.; Wanker, EE (reprint author), BIH, D-10178 Berlin, Germany.

MOLECULAR CELL, 2018; 71 (5): 675

Abstract

Self-propagating, amyloidogenic mutant huntingtin (mHTT) aggregates may drive progression of Huntington's disease (HD). Here, we report the developmen......

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