Novel anti-4-1BBxPD-L1 bispecific antibody augments anti-tumor immunity through tumor-directed T-cell activation and checkpoint blockade

Jeong, S; Park, E; Kim, HD; Sung, E; Kim, H; Jeon, J; Kim, Y; Jung, UJ; Son, YG; Hong, Y; Lee, H; Lee, S; Lim, Y; Won, J; Jeon, M; Hwang, S; Fang, L; Jiang, WQ; Wang, ZY; Shin, EC; Park, SH; Jung, J

Park, SH (corresponding author), Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon, South Korea.; Jung, J (corresponding author), ABL Bio Inc, Seongnam, South Korea.

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (7):

Abstract

Background Stimulation of 4-1BB with agonistic antibodies is a promising strategy for improving the therapeutic efficacy of immune checkpoint inhibito......

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