Pro-differentiating and radiosensitizing effects of inhibiting HDACs by PXD-101 (Belinostat) in in vitro and in vivo models of human rhabdomyosarcoma cell lines

Mararnpon, F; Di Nisio, V; Pietrantoni, I; Petragnano, F; Fasciani, I; Scicchitano, BM; Ciccarelli, C; Gravina, GL; Festuccia, C; Del Fattore, A; Tombolini, M; De Felice, F; Musio, D; Cecconi, S; Tini, P; Maddalo, M; Codenotti, S; Fanzani, A; Polimen

Mararnpon, F (reprint author), Sapienza Univ Rome, Policlin Umberto 1, Dept Radiotherapy, Rome, Italy.

CANCER LETTERS, 2019; 461 (): 90

Abstract

This study describes the in vitro and in vivo activity of PXD-101 (Belinostat), a novel hydroxamic acid-type pan-HDACs inhibitor characterized by a la......

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