NP1867, a potent, selective, covalent small molecule inhibitor of DNA Mismatch Repair (MMR) protein PMS2, functionally inhibits MMR in cells and elicits COSMIC mutational signatures consistent with MMR-deficient patient samples-MedSci.cn

NP1867, a potent, selective, covalent small molecule inhibitor of DNA Mismatch Repair (MMR) protein PMS2, functionally inhibits MMR in cells and elicits COSMIC mutational signatures consistent with MMR-deficient patient samples

Blagg, J; Riou, P; Hervieu, A; Piumatti, E; Rospo, G; Arunachalam, S; Meier, B; Weeks, S; Rodriguez, M; Parmar, K; Patel, P; Peall, A; Tongue, P; McLaren, T; Workman, R; Bago, R; Robjohns, S; Beaumont, R; Briggs, M; Langley, G; Nichols, C; Clark, D; Winship, P; Rousseau, B; Baker, M; Drysdale, M; Germano, G; Bardelli, A

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NP1867, a potent, selective, covalent small molecule inhibitor of DNA Mismatch Repair (MMR) protein PMS2, functionally inhibits MMR in cells and elicits COSMIC mutational signatures consistent with MMR-deficient patient samples

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