Screening and antitumor effect of an anti-CTLA-4 nanobody

Wan, RR; Liu, AQ; Hou, XQ; Lai, ZQ; Li, JP; Yang, N; Tan, JT; Mo, FZ; Hu, ZX; Yang, XM; Zhao, YX; Lu, XL

Zhao, YX; Lu, XL (reprint author), Guangxi Med Univ, Natl Ctr Int Res Biol Targeting Diag & Therapy, Guangxi Key Lab Biol Targeting Diag & Therapy Res, Collaborat Innovat Ctr Targeting Tumor Diag & The, Nanning 530021, Guangxi, Peoples R China.

ONCOLOGY REPORTS, 2018; 39 (2): 511

Abstract

Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a critical negative regulator of immune responses. CTLA-4 is rapidly upregulated following T-cell activat......

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