Optimisation of momelotinib with improved potency and efficacy as pan-JAK inhibitor

Desai, J; Patel, B; Gite, A; Panchal, N; Gite, S; Argade, A; Kumar, J; Sachchidanand, S; Bandyopadhyay, D; Ghoshdastidar, K; Patel, H; Chatterjee, A; Mahapatra, J; Sharma, M; Giri, P; Kumar, S; Jain, M; Sharma, R; Desai, R

Desai, J (通讯作者)，Cadila Healthcare Ltd, Zydus Res Ctr, Sarkhej Bavla NH 8A, Ahmadabad 382210, Gujarat, India.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022; 66 ():

Abstract

Dysregulated JAK-STAT signaling has been proven to be involved in several immune-mediated diseases. Several janus kinase (JAK) inhibitors have been ap......

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