GSDMD membrane pore is critical for IL-1 beta release and antagonizing IL-1 beta by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis

Luan, JY; Chen, W; Fan, JJ; Wang, SF; Zhang, XY; Zai, WJ; Jin, X; Wang, YC; Feng, ZY; Zhang, JH; Liu, ML; Ju, DW

Ju, DW (corresponding author), Fudan Univ, Sch Pharm, Minist Educ, Dept Microbiol & Biochem Pharm, Shanghai 201203, Peoples R China.; Ju, DW (corresponding author), Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China.; Liu, ML (corresponding author), Univ Penn, Perelman Sch Med, Dept Dermatol, Philadelphia, PA 19104 USA.

BIOMATERIALS, 2020; 227 ():

Abstract

Excessive release of interleukin-1 beta (IL-1 beta) is well-known to provoke cascades of inflammatory responses thus contributing to the pathogenesis ......

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