ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling

Schmidt, S; Schumacher, N; Schwarz, J; Tangermann, S; Kenner, L; Schlederer, M; Sibilia, M; Linder, M; Altendorf-Hofmann, A; Knosel, T; Gruber, ES; Oberhuber, G; Bolik, J; Rehman, A; Sinha, A; Lokau, J; Arnold, P; Cabron, AS; Zunke, F; Becker-Pauly,

Rose-John, S (reprint author), Christian Albrechts Univ Kiel, Biochem Inst, Kiel, Germany.

JOURNAL OF EXPERIMENTAL MEDICINE, 2018; 215 (4): 1205

Abstract

Colorectal cancer is treated with antibodies blocking epidermal growth factor receptor (EGF-R), but therapeutic success is limited. EGF-R is stimulate......

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