Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease

Gomez-Mariano, G; Matamala, N; Martinez, S; Justo, I; Marcacuzco, A; Jimenez, C; Monzon, S; Cuesta, I; Garfia, C; Martinez, MT; Huch, M; de Castro, IP; Posada, M; Janciauskiene, S; Martinez-Delgado, B

Martinez-Delgado, B (corresponding author), Inst Rare Dis Res, Inst Hlth Carlos 3, Mol Genet Unit, ISCIII, Ctra. Majadahonda-Pozuelo Km2, 200, E-28220 Madrid, Spain.

HEPATOLOGY INTERNATIONAL, 2020; 14 (1): 127

Abstract

Background and aims Alpha-1 antitrypsin (AAT) is a product of SERPINA1 gene mainly expressed by hepatocytes. Clinically relevant mutations in the SERP......

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