Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents

Liu, J; Cheng, Y; Yuan, L; Liu, T; Ruan, Y; Ren, YC; Li, L; Jiang, S; Xiao, YB; Chen, JJ

Liu, J; Jiang, S; Xiao, YB (通讯作者),China Pharmaceut Univ, Sch Pharm, State Key Lab Nat Med, Nanjing 210009, Peoples R China.;Xiao, YB (通讯作者),China Pharmaceut Univ, Chongqing Innovat Inst, Chongqing 401135, Peoples R China.;Liu, J; Chen, JJ (通讯作者),Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China.;Liu, J (通讯作者),Hainan Univ, Key Lab Trop Biol Resources, Minist Educ, Sch Pharmaceut Sci, Haikou 570228, Hainan, Peoples R China.;Liu, J (通讯作者),Hainan Univ, One Hlth Inst, Sch Pharmaceut Sci, Haikou 570228, Hainan, Peoples R China.

JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (18): 13172

Abstract

Current small-molecule PD-1/PD-L1 inhibitors are mainly based on the arylmethylamine/ biphenyl core scaffold. Herein, we designed for the first time a......

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